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KMID : 0665219900030020133
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Korean Journal of Food and Nutrition
1990 Volume.3 No. 2 p.133 ~ p.139
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Isolation and Purification of Acidic Polysaccharide of Korean Red Ginseng Acting against Toxic Action of Toxohormone-L from Cancerous Ascites Fluid
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李成東/Lee, Sung Dong
黃允敬/奧田拓道/Hwang, Yoon Kyung/Okuda, Hiromichi
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Abstract
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Toxohormone-L is a lipolytic factor, found in ascites fluid of sarcoma 180-bearing mice and of patients with hepatoma. A substance that inhibited the lipolytic action of Toxohormone-L was isolated and purified from Korean red ginseng powder. This substance had a pectin-like a 1, 4-polygalacturonan backbone with some acetoxyl groups, and so was an acidic polysaccharide.
It inhibited Toxohormone-L induced liploysis in a dose dependent manner at concentrations higher than 10㎍/㎖. Purified acidic polysaccharide yield(PG_4-3 and PG_4-4 fraction) was about 0.03%. And also pectic acid that inhibited the lipolytic action of Toxohormone -L.
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KEYWORD
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